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Three years is a common time frame we hear, but that’s just from this 70-year-old autopsy study where a back-of-the-envelope calculation said that if the average liver weighs like three pounds (1.35 kg), and B12 is stored in the liver, and there’s a certain amount of B12 per gram, then the average liver would contain enough for three years––but that’s all just in theory

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Although blood levels decline relatively quickly, the compound binds to components of the extracellular matrix — essentially the structural scaffolding of the body — allowing tissue concentrations to remain elevated for 1 to 3 days